CXC chemokine ligand 2 induced by receptor activator of NF-kappa B ligand enhances osteoclastogenesis.

Receptor Activator of Nuclear Factor Kappa B Ligand (RANKL) Levels in Peri-Implant Crevicular Fluid

Background: Receptor activator of nuclear factor kappa B ligand (RANKL) is one of the key cytokines in the induction of osteoclastogenesis both in vitro and in vivo.Several reports indicated the presence of sRANKL in gingival crevicular fluid of patients with periodontal diseases. Objective: To determine the presence of RANKL in peri-implant crevicular fluid samples of implants with peri-implan...

Endogenous Production of TGF-b Is Essential for Osteoclastogenesis Induced by a Combination of Receptor Activator of NF-kB Ligand and Macrophage-Colony- Stimulating Factor

Lactosylceramide is essential for the osteoclastogenesis mediated by macrophage-colony-stimulating factor and receptor activator of nuclear factor-kappa B ligand.

Glycosphingolipids and their metabolites play important roles in a variety of biological processes. Several signal molecules are localized in a glycolipid-enriched microdomain on the cell surface, and their signals are regulated by the glycolipid composition. However, the function of glycolipids in osteoclastogenesis has not been clearly understood. We found that D-threo-1-phenyl-2-decanoylamin...

Tnf-alpha and Rankl Cooperatively Mediate Implant Particle-induced Osteoclastogenesis via Distinct Actions

Introduction: Periprosthetic osteolysis stimulated by implant particulate debris is mediated by various pro-inflammatory cytokines (TNF-alpha, IL-1, and IL-6) that enhance osteoclast differentiation and activity, yet TNF-alpha (TNF) has recently been identified as playing a critical role in this process (1,2). Specifically, in osteoclast precursor cells implant particles activate the nuclear tr...

Endogenous production of TGF-beta is essential for osteoclastogenesis induced by a combination of receptor activator of NF-kappa B ligand and macrophage-colony-stimulating factor.

Differentiation of osteoclasts, the cells primarily responsible for bone resorption, is controlled by a variety of osteotropic hormones and cytokines. Of these factors, receptor activator of NF-kappaB (RANK) ligand (RANKL) has been recently cloned as an essential inducer of osteoclastogenesis in the presence of M-CSF. Here, we isolated a stroma-free population of monocyte/macrophage (M/Mphi)-li...